The use of hyaluronic acid has accepted during some eye surgeries including corneal transplantation, cataract removal and repair of a detached retina, and other eye injuries, used in eye drops in order to prevent dry eye symptom (DES). It can be injected into eye vitreous to replace natural eye fluids by ophthalmologists.

Hyaluronic acid can be used for many joint disorders, like osteoarthritis or cartilage damage. It can be taken by mouth or injected into the affected joint by orthopedics as it increases the viscosity of the synovial fluid it can improve joint movement and patient mobility.

Some patients can apply hyaluronic acid to the skin for healing wounds, burns, skin ulcers, and as a cosmetic moisturizer. Some information is displayed that HA is essential and helpful in treating diabetic foot ulcers by enhancing the rate of wound healing and  promote angiogenesis.

Hyaluronic acid cream is a safe alternative for hormonal therapy in treatment of vaginal atrophy, it can relieve vaginal dryness in postmenopausal women.

Hyaluronic sodium solution topically can use as an alternative way to surgery especially when the perforation of tympanic membrane is small or medium sized.

Topically applying of sodium hyaluronate significantly improves patients’ QoL following FESS (Functional endoscopic sinus surgery) and stop mucosal hypertrophy.