Effect of Lysine Hyaluronate on the Healing of Decubitus Ulcers
Effect of Lysine Hyaluronate on the Healing of Decubitus Ulcers in Rehabilitation Patients
Article specifications
This double-blind randomized controlled trial was published in 2011 in Advances in Therapy journal (IF 2016: 2.709) by Italian specialists. This hypothesized that lysine hyaluronate (Lys-HA) (Lysial®, Fatai-Nyl Srl; Jasper LLC, Lugano, Switzerland), a new formulation of hyaluronic acid, would improve the healing of decubitus ulcers more than the commonly used sodium hyaluronate (SH). This study was designed over a 15-day period, and on the time necessary to reach 50% lesion size regression. 50 hospitalized patients with decubitus ulcers were divided into three groups according to ulcer stage (stage 1: erythema and edema; stage 2: all-thickness skin destruction; stage 3: destruction of subcutaneous tissue) and randomized to receive Lys-HA or SH. Digital photographs were taken before the start of treatment, then every 3 days, and at the end of the study.
Results
The use of Lys-HA in the healing process of decubitus ulcers providesan improved efficacy with respect to SH in hospitalized patients, suggesting its use from the early phases of ulceration.