Effect of Lysine Hyaluronate on the Healing of Decubitus Ulcers

Effect of Lysine Hyaluronate on the Healing of Decubitus Ulcers.jpg

Effect of Lysine Hyaluronate on the Healing of Decubitus Ulcers in Rehabilitation Patients

Article specifications

This double-blind randomized controlled trial was published in 2011 in Advances in Therapy journal (IF 2016: 2.709) by Italian specialists. This hypothesized that lysine hyaluronate (Lys-HA) (Lysial®, Fatai-Nyl Srl; Jasper LLC, Lugano, Switzerland), a new formulation of hyaluronic acid, would improve the healing of decubitus ulcers more than the commonly used sodium hyaluronate (SH). This study was designed over a 15-day period, and on the time necessary to reach 50% lesion size regression. 50 hospitalized patients with decubitus ulcers were divided into three groups according to ulcer stage (stage 1: erythema and edema; stage 2: all-thickness skin destruction; stage 3: destruction of subcutaneous tissue) and randomized to receive Lys-HA or SH. Digital photographs were taken before the start of treatment, then every 3 days, and at the end of the study.

 

Results

The use of Lys-HA in the healing process of decubitus ulcers providesan improved efficacy with respect to SH in hospitalized patients, suggesting its use from the early phases of ulceration.

Tags: Italy advances in therapy Clinical trial 2011

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