Systematic review of the efficacy of topical hyaluronic acid on oral ulcers

Systematic review: the efficacy of topical hyaluronic acid on oral ulcers.

Article specifications

This review article was published in 2017 in journal of biological regulators and homeostatic agents (IF 2016: 2.38) by Italian specialists.  The aim of the study is to systematically review the published literature regarding all the therapeutic effects of HA on painful oral lesions such as oral ulcers and oral lichen planus. Relevant published studies were found in PubMed, Google Scholar and Ovid using a combined keyword search or medical subject headings. At the end of our study selection process, 4 relevant publications were included: two regarding oral lichen planus, one Behcets Disease and Recurrent Aphthous ulcer and one in oral ulcers in general. Both subjective parameters such as healing period, VAS for pain and objective assessments such as number of ulcers, maximal area of ulcer and inflammatory signs, significantly improved after HA treatment. 

 

Results

These data allow us to suggest that HA may play a pivotal role in the treatment of oral ulcers.

Tags: Italy biological regulators and homeostatic agents systematic reviews 2017

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