Evaluation of Hyaluronic Acid Gel in Gingivitis

An Evaluation of 0.2% Hyaluronic Acid Gel (Gengigel^®) in the Treatment of Gingivitis: A Clinical & Microbiological Study.

Article specifications

This longitudinal, randomized, and placebo-controlled clinical trial was published in 2014 in Oral Health and Dental Management Journal (IF 2015: 0.65) by Indian dentists. This study evaluate the therapeutic efficacy of 0.2% Hyaluronic Acid Containing Gel (Gengigel®) in cases of gingivitis as an adjunct to scaling. This 4 week clinical and microbiological trial included 105 subjects comprising of both the sexes, age ranging from 15-40 years. Patients who diagnosed as suffering from chronic gingivitis, bleeding while brushing and at least 2-3 interproximal sites affected in each of four quadrants, with minimum 20 remaining teeth in the oral cavity were included in study. Subjects selected had at least 2-3 interproximal sites in each quadrant exhibiting bleeding on probing. All patients divided in 3 equal groups of 35 each:

1. Negative control group: Scaling.
2. Placebo control group: Scaling plus placebo gel twice daily..
3. Test group: Scaling plus Hyaluronic Acid Gel twice daily.

The clinical parameters Plaque Index (PI), Gingival Index(GI) and Papilla Bleeding Index (PBI) were determined at intervals of 1 week, 2 weeks and 4 weeks from baseline, microbiological parameters were monitored at the interval of 4 weeks from baseline.

Results

An improvement of all clinical variables was observed for all treatment modalities. Clinically, there is significant difference for GI & PBI in test group as compared to other groups, but reduction in PI was non-significant. In negative control and placebo control groups, the difference between clinical parameters was non-significant. Statistically significant reduction in percentage of anaerobic gram-negative bacilli and relative increase of gram positive coccoid cells was seen in all treatment groups at 4 weeks as compared to baseline.