Hyaluronic Acid in treatment of gingivitis

Treatment of gingivitis with hyaluronan.

Article specifications

This randomised double-blind study was published in 2003 in Journal of Clinical Periodontology (IF 2013:4.86) by German specialists. in this study, it was evaluated in a gel formulation for its effect in the treatment of plaque-induced gingivitis. 50 male subjects (mean age 29.9±10.5 years) with plaque induced gingivitis were divided into two groups and used a verum or placebo gel twice daily additionally to oral hygiene for a 3-week treatment period. Clinical indices (API, Turesky index, PBI) and crevicular fluid variables (peroxidase, lysozyme) were determined at baseline and after 4, 7, 14 and 21days, respectively.

Results

Significant improvements could be found for all clinical variables in both groups. The verum group showed significant improvement in the study area for the plaque indices beginning with day4 and the PBI beginning with day7 in comparison with the placebo group. The crevicular fluid variables were significantly improved in the centre of the studied inflammation area in the verum group. Here all studied sites had significant decreases in peroxidase and lysozyme activities after 7, 14 and 21 days, whereas in the placebo group only one site showed a significant decrease for lysozyme after 7 and 21 days. These data suggest that a hyaluronan containing gel has a beneficial effect in the treatment of plaque-induced gingivitis.