hyaluronan in the treatment of gingivitis in orthodontic patients

Use of hyaluronan (Gengigel) in the treatment of gingivitis in orthodontic patients: A clinical, biochemical, and microbiological study.

Article specifications

This randomized, controlled, parallel design study was published in 2016 in Journal of the International Clinical Dental Research Organization by Indian specialists. Aim of the present study was to compare the effects of hyaluronan (Gengigel) alone and in combination with scaling using clinical, microbial, and lactate dehydrogenase (LDH) parameters. Thirty-two patients in the age group of 18-25 years undergoing orthodontic treatment with plaque-induced gingivitis with a probing depth <3 mm was selected. The three treatment groups included were scaling, scaling plus local application of Gengigel, and Gengigel alone. The 0.2% hyaluronic acid (HA) gel was applied topically and intrasulcularly 0.8% hyaluronan was applied. Prior to the treatment, the indices assessed included clinical parameters: Plaque index (PI), gingival index (GI), and gingival bleeding index (GBI); microbial assessment and biochemical analysis of GCF LDH. These were recorded by the main investigator and were repeated on days 0 and day 28. Any adverse reactions to the gel were also recorded. The duration of the study was 56 days.

 

Results

At the end of study period (0-56 day), intergroup comparison demonstrated no significant reduction in plaque index (PI) , gingival index (GI), and LDH values. A significant correlation was found between LDH values and bleeding index at all study intervals (0 days, 28 days, and 56 days); gingival index (GI) was significantly correlated on day 0 and day 56. The microbial reduction was demonstrated. These changes in the clinical, microbial, and biochemical parameters reported with the different treatment modalities clearly support that the use of Gengigel would act as an advantageous adjunct to scaling.