hyaluronic acid in gingivitis therapy

The clinical application of hyaluronic acid in gingivitis therapy.

Article specifications

This clinical study was published in 2014 in Journal of Clinical and Diagnostic Research (IF 2014:0.65) by Indian specialists. Aim of the present study was to evaluate the efficacy of a topical application of hyaluronic acid (HA) for treating gingivitis. Sixty nonsmoking outpatients in good general condition, with clinical signs of gingivitis, were included in the study. Forty patients (HA group, 20 men, 20 women;  used a spray containing HA 5 times daily over a period of 1 week. The control group consisted of 20 patients (10 men, 10 women). The clinical parameters DMF-T (decayed, missed, filled teeth) index, approximal plaque index, sulcus bleeding index, papilla bleeding index, and gingival crevicular fluid were measured at baseline (T1), after 3 days (T2), and after 7 days (T3).

Results

A reduction in the sulcus bleeding index of the HA group was noted at T2. The gingival crevicular fluid showed significant reductions in the HA group. Only insignificant changes were observed in the respective indices of the control group. There were no significant alterations in the plaque values of either group throughout the study period. The results obtained by this study demonstrate that the topical application of an HA-containing preparation represents a potentially useful adjunct in the therapy of gingivitis, although its use does not diminish the need for plaque reduction as a primary therapeutic measure.