Efficacy of hyaluronic acid in oral lichen planus

Efficacy of hyaluronic acid in oral lichen planus.jpg

The efficacy of topical hyaluronic acid in the management of oral lichen planus

Article specifications

This randomized, placebo-controlled, double blind clinical study was published in 2009 in Journal of Oral Pathology & Medicine (IF 2016:2.043) by British specialists. The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) gel preparation (0.2%) in the management of oral lichen planus (OLP). A total of 124 patients with erosive OLP participated in this trial to evaluate the efficacy of a topical HA preparation. Outcome measures included soreness relief following immediate application, oral function and size of erosive ⁄ ulcerative area. Patients were medicated for 28 days and completed a log diary recording oral function and soreness scores. A total of 124 patients with erosive OLP participated in a randomized, placebo-controlled, double blind trial to evaluate the efficacy of a topical HA preparation. Outcome measures included soreness relief following immediate application, oral function and size of erosive ⁄ ulcerative area. Patients were medicated for 28 days and completed a log diary recording oral function and soreness scores.

Results

Application of topical HA produced a significant reduction in soreness scores when compared with placebo for up to 4 h post-application. There was no difference between treatment groups with respect to oral function. Patients treated with 0.2% HA showed a significant reduction in the size of the erosive ⁄ ulcerated area after 28 days of treatment when compared with baseline. There was no significant difference in changes in ulcerative areas between treatment groups. Topical HA (0.2%) does appear to be of some benefit in the management of erosive lichen planus providing efficacy for up to 4 h after administration. Very frequent applications should be considered to obtain a more significant clinical benefit. Topical HA gel may be a useful addition to the treatment option for OLP.

Tags: Britain Clinical trial Oral Pathology & Medicine 2009

Hayland Center

© 2018 HYLAND.CENTER ALL RIGHTS RESERVED