Effect of hyaluronic acid gel on periodontitis

Effect of hyaluronan on periodontitis: A clinical and histological study.

Article specifications

This randomized, controlled, parallel design study was published in 2012 in Journal of Indian Society of Periodontology (IF 2015:0.65) by Indian dentists. The aim of this study was to investigate the clinical and histological outcomes of local subgingival application of 0.2% hyaluronic acid gel (GENGIGEL®) as an adjunct to scaling and root planting (SRP) in chronic periodontitis patients. One hundred and twenty sites were chosen from 26 patients (Inclusion criteria for the study were patients with pocket depths ≥5 mm, adequate attached gingiva, and age range between 25 to 55 years.) with chronic periodontitis. Clinical parameters such as Gingival index (GI), Bleeding index (BI), Probing Pocket Depth (PPD), and Relative Attachment Level (RAL) were recorded at baseline (0 day), 4th, 6th, and 12th week. At the time of baseline examination, no significant differences were observed in GI, BI, and PPD in the test and control group. Experimental sites additionally received HA gel subgingivally at baseline, 1st, 2nd, and 3rd week. At 4th week recall, a gingival biopsy was obtained from test and control site for histologic examination.

Results

Intra-group analysis of all the clinical parameters at all sites from baseline to 4th, 6th, and 12th week showed statistically significant changes. Experimental sites showed statistically significant improvement in Gingival index and Bleeding index at 6th and 12th week when compared with control sites. However, no statistically significant differences were observed in the PPD and RAL between control and experimental sites at 4th, 6th, and 12th week time interval. No statistically significant association was found between the histological grading of the sites that received HA treatment.