antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction

The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction.

Article specifications

This double blind, randomized, and controlled clinical trial was published in 2015 in Journal of Cranio-Maxillofacial Surgery (IF 2016: 1.252) by Turkish specialists. The purpose of this study is to measure the efficacy of high molecular weight HA on wound healing considering biochemical and histological parameters after M3 extractions. 40 patients were included in this study. 0.2 ml 0.8% HA was applied immediately after surgery within the HA group (n ¼ 20). Nothing was applied to the control group (n ¼ 20). The primary outcome variables were the changes in the inflammatory reaction (leucocyte, angiogenesis and collagen content), oxidative stress (GSH, LPO) and clinical parameters (VAS, MIO). Results were compared immediately after extraction (T0) and 1 week after surgery (T1). Bivariate analyses were used to assess the differences between the HA and control groups for each study variable.

Results

There was a statistically significant difference of leucocyte infiltration and angiogenesis between the groups at T1. The HA group showed less leucocyte infiltration and more angiogenesis than the control group. There was no statistically significant difference in oxidative stress, VAS or MIO levels between the groups. Our results confirm the hypothesis that HA has an anti-inflammatory effect following M3 extraction. However, the oxidative stress levels and clinical outcomes were similar after one week.