Systematic Review of efficacy of topical hyaluronan in rhinosinusitis

The efficacy of topical hyaluronan in rhinosinusitis: a systematic review.

Article specifications

This systematic review was published in 2017 in Journal of biological regulators and homeostatic agents (IF 2015: 1.469) by Italian and Spanish specialist. The aim of the study is to systematically review the published literature regarding all the therapeutic effects of HA on the ARS and CRS. Relevant published studies were found in PubMed, Google Scholar and Ovid, using a combined keyword search or medical subject headings. At the end of our study selection process, 5 relevant publications were included: 2 of them investigated the potential role of HA in reducing symptoms and preventing exacerbations of CRS in adult population, two of them in pediatric patients affected by upper respiratory tract infections and one of them in cystic fibrosis patients with bacterial rhinopharyngitis.

 

Results

Data deriving from the present review of 5 clinical studies showed that the use of topical HA represents a relevant therapeutic advance in rhinosinusitis to minimize symptoms and prevent reacutization with a significant improvement of their quality of life, as it avoids systemic side effects and increases local drug activity.