An Effectiveness Study of Hyaluronic acid【Hyabest® (J)】 in the Treatment of Osteoarthritis of the Knee on the Patients in the United States.

An Effectiveness Study of Hyaluronic acid【Hyabest® (J)】 in the Treatment of Osteoarthritis of the Knee on the Patients in the United States.

Article specifications

This placebo controlled, double blind clinical trial was published in 2009 in japanese journal of new remedies and clinics by Japanese orthopedics. In this study, they test on 37 patients who were age 40 or above and lived in the United States and at the same time classified into the grade II or III of Kellgren-Lawrence classification by the radio-graph. Patients were orally fed with 200mg/day of high purity hyaluronic acid (Hyabest® (J)) for 8-weeks. Effectiveness in the reduction of pain in the knee joints was assessed by the changes in WOMAC (Western Ontario McMaster universities Osteoarthritis Index) scores. At the same time safety of the oral intake of Hyabest (J) was examined by blood tests conducted at pre-and-after administration. The test conducted for the period of 8-weeks. 3-observation time points were programmed; pre-administration, 4-weeks of administration and 8-weeks of administration.

 

Results

Significant improvement in WOMAC scores was observed after 4-weeks of oral intake in the group of Hyabest (J).As the group of placebo also showed decline in WOMAC scores there was no statistically significant differences observed between the two groups. However, in the analysis of the scores of patients only suffering from severe pain the Hyabest (J) group has shown significant improvement over the placebo group. No adverse changes for safety were detected from the blood test readings. The above study result suggests that oral intake of high purity hyaluronic acid (Hyabest (J)) is effective in the treatment of American patients of knee osteoarthritis.

Tags: Japan J.New Rem.&Clin Clinical trial 2009

Hayland Center

© 2018 HYLAND.CENTER ALL RIGHTS RESERVED