Effects of oral administration of yoghurt supplemented with hyaluronic acid on mild joint discomfort
Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (MobileeTM) in adults with mild joint discomfort: a randomized, double-blind, placebo-controlled intervention study.
Article specifications
This randomized, double-blind, placebo-controlled clinical trial was published in 2013 in mediterranean journal of nutrition and metabolism (IF 2015:1.13) by Spanish specialists. The aim of this study was to determine the efficacy of the oral administration of yoghurt supplemented with HA (MobileeTM) in healthy individuals with mild joint discomfort. 40 Patients were adults of both sexes aged between 50 and 75 with Mild joint discomfort and Symptomatic joint discomfort for a minimum of 6 months. Supplemented group ate yoghurt supplemented with 80 mg of a preparation containing hyaluronic acid (65 %) from rooster comb (MobileeTM) per day for a period of 90 days. The stability of HA in the yoghurt matrix for a period of 4 weeks was assessed before the beginning of the study. The control group (CT) ate yoghurt per day without any supplement. Subjects were told not to take analgesics or non-steroidal anti-inflammatory drugs. Only paracetamol (500 mg) was allowed as a pain reliever. The selected participants were randomly distributed and given the isokinetic test, the Lequesne index and SF-36 survey at the inclusion visit, 1 day prior to the consumption of the first yoghurt. The Lequesne index and SF-36 survey were repeated in weeks 4 and 8 after the start of the nutritional intervention period. At the end of the study (12 weeks), a complete clinical assessment was repeated, including a global subject-satisfaction assessment.
Results
According to data, the improvement in work load and peak torque observed in this study may be secondary to a reduction in joint discomfort as a result of an improvement in the synovial fluid. However, a direct effect of HA on muscle tissues should not be ruled out. Further research is necessary to confirm this point because in this study, the functional scales (Lequesne index) and pain assessment (visual analog scale) were not suitable for the participants’ clinical conditions. It can be stated that oral supplementation with a preparation containing HA improved joint mechanics and muscle function as determined through isokinetic testing, thus attenuating risk factors of OA.
