Is Local Viscosupplementation Injection Clinically Superior to Other Therapies in the Treatment of Osteoarthritis of the Knee: A Systematic Review of Overlapping Meta-analyses
This systemic review was published in 2015 in Journal of Arthroscopy (IF 2014:1.40) by American specialist. The purpose of this study was to conduct a systematic review of overlapping meta-analyses comparing treatment of knee osteoarthritis (OA) with intra-articular viscosupplementation (intra-articular hyaluronic acid [IA-HA]) versus oral nonsteroidal antiinflammatory drugs (NSAIDs), intra-articular corticosteroids (IA-corticosteroids), intra-articular platelet-rich plasma (IA-PRP), or intra-articular placebo (IA-placebo) to determine which meta-analyses provide the best current evidence and identify potential causes of discordance.
According to this systematic review of overlapping meta-analyses comparing IA-HA with other nonoperative treatment modalities for knee OA, the current highest level of evidence suggests that IA-HA is a viable option for patients with knee OA. Its use results in improvements in knee pain and function that can persist for up to 26 weeks in comparison with other treatment modalities. IA-HA has been shown to have a good safety profile, and its use should be considered in patients with early knee OA.