Hyaluronic Acid as an Adjunct to Scaling and Root Planing in Chronic Periodontitis

Local Delivery of Hyaluronan as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis.

Article specifications

This randomized clinical study was published in 2009 in Journal of Periodontology (IF 2014: 2.04) by swiss, Swedish and Georgian specialists. The aim of the present study was to evaluate the adjunctive effect of the local application of a hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis. Twelve patients (aged 42 to 63 years (seven men, aged 54 – 8 years, and five women aged 56 – 7 years)) with chronic periodontitis were recruited to participate in a study with a split-mouth design and provided informed consent. Plaque formation and bleeding on probing were evaluated pretreatment (baseline) and at 1, 4, and 12 weeks post-treatment. Probing depths and attachment levels were evaluated at baseline and at 12 weeks. The patients received full-mouth scaling and root planing. A hyaluronan gel was administered subgingivally in the test sites at baseline and after 1 week. Significant differences between test and control were evaluated using the paired t test, repeated-measures analysis of variance (Wilks lambda), and a non-parametric Wilcoxon signed-rank test.

 

Results

A significant reduction in bleeding on probing scores and probing depths was observed in both groups at 12 weeks. Significantly lower bleeding on probing scores were observed in the hyaluronan group compared to control at 12 weeks. Mean probing depth reductions between baseline and 12 weeks were 1.0 – 0.3 mm and 0.8 – 0.2 mm for the hyaluronan and control groups, respectively. The difference between the groups was statistically significant.