Effect of hyaluronic acid on the osseointegration of dental implants.
This clinical trial was published in 2019 in Journal of Br J Oral Maxillofac Surg. (IF 2018: 0.46) by Turkish specialists. The purpose of this study was to investigate the effects of hyaluronic acid gel on the osseointegration of implants placed in defined areas of the mandible in rabbits. Ten New Zealand rabbits aged 10 weeks and weighing 2.5-3.0kg were used, and sites for implants that were far enough from the apices of the teeth in the mandibular molar area were chosen. Two cavities were prepared in each rabbit, one (anterior) for the control implant, and one (posterior) for the implant with hyaluronic acid gel (Medical Instinct GmbH, Bovenden).
New bone and the osteoid matrix content around the dental implants were evaluated histologically and histomorphometrically two months after the operation, and no significant difference was found between the two groups. The hyaluronic acid may have had a favourable impact on healing of soft tissue and bone.