Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial.
This randomized clinical study was published in 2013 in Journal of Periodontology (IF 2014:2.04) by swiss specialists. The study is designed to determine the effect on clinical variables, subgingival bacteria, and local immune response brought about by application of hyaluronan-containing gels in early wound healing after scaling and root planing (SRP). 34 individuals (18 males and 24 females, aged 41 to 72 years) with chronic periodontitis were evaluated after full-mouth SRP. All patients used a chlorhexidine digluconate mouthwash for 1 minute twice daily during the first 7 days after SRP and carefully performed normal oral hygiene with a toothbrush and interdental brush. In the test group (n = 17), hyaluronan gels in two molecular weights (1,800 kDa and 1,000 kDa) were additionally applied during the first 2 weeks after SRP. The control group (n = 17) was treated with SRP only. Probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid samples were taken for microbiologic and biochemical analysis.
In both groups, PD and CAL were significantly reduced. The changes in PD and the reduction of the number of pockets with PD ‡5 mm were significantly higher in the test group after 3 and 6 months. Six months after SRP, the counts of Treponema denticola were significantly reduced in both groups, as were those of Campylobacter rectus in the test group only. Prevotella intermedia and Porphyromonas gingivalis increased in the control group. This study indicates possible antibacterial effects of high-molecular-weight HA on periodontopathogenic bacteria as an adjunct to SRP.