Comparison of hyaluronic acid plus silver sulfadiazine vs. silver sulfadiazine alone in 2nd degree burns

Second-degree burns: a comparative, multicenter, randomized trial of hyaluronic acid plus silver sulfadiazine vs. silver sulfadiazine alone

Article specifications

This comparative, multicenter, randomized, double-blind, controlled, parallel-group trial was published in 2005 in Current Medical Research and Opinion Journal (IF 2016: 2.757) by French surgeon. This study was designed to assess the efficacy and safety of a fixed combination topical medicinal product, containing 0.2% hyaluronic acid and 1% silver sulfadiazine (HA-SSD) (Connettivina* Plus cream) versus 1% silver sulfadiazine cream alone (SSD), in the treatment of second-degree burns. 111 adult patients were (age 18–75 years) of both sexes, with IIa-degree (superficial) and IIb-degree (deep dermal) burns. Each patient, after an accurate debridement and cleaning of the burn wound with appropriate antibacterial solutions, were randomized to receive HA-SSD or SSD. Treatments (approximately 5 g/100 cm2) were applied once a day until the wounds healed, but for no longer than 4 weeks. Burns had to have occurred within 48 hours from the start of treatment, be caused by thermal injury, and be confined to the trunk and/or upper and lower extremities. Plasma biochemistry tests were carried out at Day 0 and at the final day of the study for each patient.

 

Results

In this study, All burns were healed except in one patient treated with SSD. It was also observed that the fixed combination HA-SSD caused a significantly more rapid re-epithelialization of burns, i.e. a shorter time to healing, than SSD alone. The difference recorded – 4.5 days – was statistically significant.