The use of different HA-based products in patients with chronic skin ulcers of various etiologies (vascular, scleroderma, postoperative) to assess the indication, effectiveness, and possible adverse reactions
Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.
Article specifications
This case review study was published in 2019 in Journal of Wounds. (IF 2013:0.53) by Italian specialists. This retrospective, observational study examined the use of different HA-based products in patients with chronic skin ulcers of various etiologies (vascular, scleroderma, postoperative) to assess the indication, effectiveness, and possible adverse reactions.
Result
The negative effects of HA-based products on a patient with scleroderma could be explained by the fact that HA can produce a proinflammatory effect causing keratinocyte migration.
Tags: Italy Review article 2019 Wounds