Effect of hyaluronan, KI3, and their combination on progression of wound healing in excision skin wounds in rats

Preclinical evaluation of wound treatment with hyaluronan-iodine hydrogel.

Article specifications

This clinical trial was published in 2012 in Journal of Wounds. (IF2012: 0.77) by Czech specialists. The aim of this study was to evaluate the possible toxic effects of iodine after Hyiodine application for wound healing, iodine systemic absorption from the Hyiodine-treated wounds and its distribution profile were quantitatively described and compared after intravenous iodide administration using 131I as a radiolabel.

 

Results

Treatment of rats with Hyiodine resulted in an enhancement of wound healing, proved by greater degrees of wound contraction and reduction in mean wound healing time compared to other treated rats on hours 1, 2, 24, and 216. A hyaluronan-iodine hydrogel has a great potential for effective treatment of wounds.