Correction of Nasolabial folds with Hyaluronic acid

Safety and efficacy of hyaluronic acid for the correction of nasolabial folds: a meta-analysis.

Article specifications

This meta-analysis was published in 2013 in Journal of Eur J Dermatol. (IF 2013:1.01) by Chinese specialists. The aim of this study was to evaluate and compare the safety and efficacy of different types of hyaluronic acid (HA) for nasolabial fold correction. A literature search, using MEDLINE, PubMed and Google Scholar, and a manual search of references for additional relevant studies were performed. Randomized controlled trials (RCTs) and clinical trials (CTs) with 0.5-24 months' duration, evaluating efficacy and safety after for HA augmentation therapy, were included. Overall, 18 RCTs (n = 2,521) and 7 CTs (n = 346) were included.

 

Results

Our meta-analysis proved both safety and efficacy for HA fillers. Juvederm™ family achieved the best efficacy, while the adverse event incidence for Juvederm™ family was significantly higher than for other HA products.