Comparison of four fillers: PRI 1, PRI 2, Zyplast® and Perlane

A double-blind, clinical evaluation of facial augmentation treatments a comparison of PRI 1, PRI 2, Zyplast^® and Perlane^®

Article specifications

This clinical trial was published in 2009 in Journal of J Plast Reconstr Aesthet Surg. (IF 2009: 0.82) by Britannia specialists. 79 females (aged 25-55 years) with wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane (23 patients), Zyplast (18 patients). Patients were assessed at 1 week and 1, 3, 6, 9 and 12 months using 2D images and by mathematically derived facial volume changes using 3D stereophotogrammetry.

 

Results

Results showed that PRI 1 and PRI 2 were comparable to Perlane and Zyplast as dermal fillers. Further rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry for assessment of volume changes.