Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women

Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women.

Article specifications

This Randomized Controlled clinical trial was published in 2016 in Int J Community Based Nurs Midwifery by Iranian specialists. In this study 56 Married and menopause women, existence of moderate to severe dryness at the vaginal region, endometrial thickening with vaginal sonography maximum 5mm were among the inclusion criteria. with symptoms of vaginal atrophy randomly divided in two Group (A) received conjugated Estrogen 0.625 mg cream one applicator of drug (0.058 mg) every night before sleep for a period of two weeks and two times a week for the next six weeks and group B received Hyaluronic Acid vaginal cream (containing 5 mg sodium salt) used one applicator 5mg every night before sleep for a period of 8 weeks. The severity of each sign of atrophy was evaluated by visual analog signals (VAS). Also, to recognize the cellular maturation with pap smear and the maturation degree were calculated according to the formula and scores 0-100. As the vaginal PH, we used PH marker band, the rate of which was divided into 4 degrees

Results

This study showed the better and more relief of the symptoms of urinary incontinence, cellular maturation and vaginal dryness in menopause women in the hyaluronic acid cream therapeutic group compared with Estrogen-therapy group. Urinary incontinence only showed improvement in the hyaluronic acid group. Improvement in urinary incontinence, dryness, maturation index and composite score of vaginal symptoms in the hyaluronic acid group was better than those in the Premarin group.

hyaluronic acid was more effective and this drug is suggested for those who do not want to or cannot take local hormone treatment. Therefore, the hyaluronic acid could be a suitable alternative for treatment of vaginal atrophy with estrogen.