Effect hydroxypropyl methylcellulose 2.0%, sodium hyaluronate 3.0%–chondroitin sulfate 4.0%, sodium hyaluronate 1.4%, and Healon5® (sodium hyaluronate 2.3%)substances on intraocular pressure and endothelium after cataract surgery

Effect of Healon5 and 4 other viscoelastic substances on intraocular pressure and endothelium after cataract surgery. A Randomize, Prospective clinical trial.

Article Specifications

This clinical trial was published in 2001 in Journal of cataract and refractive surgery (IF2015: 2.72) by German ophthalmologists. In this study the authors compared different types of ophthalmic viscoelastic devises during phacoemulsification and intraocular lens implantation in terms of influence on intraocular pressure (IOP) postoperatively and endothelial cells preoperatively and postoperatively. This clinical trial comprised 81 eyes 74 eyes completed all preoperative and 5 postoperative examinations. The OVDs used were:

OcuCoatT^® and CeloftalT^® (hydroxypropyl methylcellulose 2.0%)

ViscoatT^® (sodium hyaluronate 3.0%–chondroitin sulfate 4.0%)

Healon GVT (sodium hyaluronate 1.4%)

Healon5^® (sodium hyaluronate 2.3%)

Intraocular pressure was measured by standard Goldman applanation tonometry preoperatively and 4 to 6 and 24 hours and 7, 30, and 90 days postoperatively. Endothelial cell counts were done preoperatively and 90 days postoperatively using a Pro/Koester WFSCM contact endothelial microscope.

Results

In conclusion, no severe postoperative complications such as a high IOP rise were observed with any OVD. However, endothelial cell loss was significantly lower with the viscoadaptive Healon5.