Evaluate the protective effect of sodium-hyaluronate 1% (Biolon) use on corneal endothelium, during donor’s corneal harvesting

The Use of Ophthalmic Viscosurgical Devices During donor’s Corneal Harvesting.

Article specifications

This prospective, randomized, double blind, comparative clinical trial was published in 2013 in Curr Eye Res. of modern optic (IF 2016:1.328) by Israeli ophthalmologists. This clinical trial included 120 cornea donor divided in 2 groups: 60 was harvested using intracameral injection of ophthalmic viscosurgical device (OVD), and the fellow cornea with no use of OVD (n: 60, control group). Endothelial cell density (ECD) values were obtained at the center of each corneal graft with a specular microscope one day after harvesting. Sodium-hyaluronate is one of the most common OVDs used in phacoemulsification surgery.

Results

This article showed that Intracameral OVD injection (HA injection) during corneal graft harvesting may protect the endothelium from the mechanical damage induced during the procedure. Further investigation is needed before routine the use of intracameral OVD should be considered in this setting. we have shown here another possible benefit of viscoelastic substance-use during ocular surgery, particularly in corneal harvesting.