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The effect of two hyaluronic acid/trehalose-based containing formulations on the signs and symptoms in patients with moderate to severe dry eye disease (DED).

Effect of Hyaluronic Acid Trehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease.

Article specifications

This randomized, observer-masked, crossover study was published in 2018 in Journal of Ophthalmology (IF 2014:6.1) by Austrian, Romanian, Polish and Singaporean specialists. The aim of the present study was to evaluate the effect of two hyaluronic acid/trehalose-based containing formulations, with different physical properties, on the signs and symptoms in patients with moderate to severe dry eye disease (DED). In one group, patients received a mixture of sodium hyaluronate and trehalose (HT, ,ealoz Duo®) for use during the day. In the other group, patients received a more viscous formulation consisting of hyaluronic acid, trehalose, and carbomer (HTC-gel, ,ealoz Duo Gel) to use pro re nata.

Results

The results show improvement in signs and symptoms of DED in both groups. While instillation of HTC-gel resulted in a lower instillation frequency, both formulations of trehalose showed good clinical efficacy.

Tags: Austria Poland Clinical trial Ophthalmology 2018 Singapore Romania

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