Comparative Analysis of Carmellose 0.5% Versus Hyaluronate 0.15% in Dry Eye: A Flow Cytometric Study

Comparative Analysis of Carmellose 0.5% versus Hyaluronate 0.15% in Dry Eye: A Flow Cytometric Study. A Randomized, Masked-observer, Parallel group, Single-center study

Article Specifications

This clinical trial was published in 2010 in Journal of cornea (IF 2017:2.010) by Spanish ophthalmologists. In this study the efficacy of Viscofresh 0.5% (carmellose sodium 0. 5%) versus Lubristil (sodium hyaluronate 0.15%) in dry eye syndrome were compared and the influence of these two treatments on the expression of various inflammatory markers by flow cytometry in impression cytology specimens were studied.  15 patients with dry eye syndrome divided in 2 groups treated with Carmellose 0.5% or Sodium hyaluronate 0.15% 4 drops daily for a month. Corneal staining with fluorescein, breakup time, Schirmer 1 test with anesthesia (Jones test), and tear clearance were assessed. Besides, conjunctival impression cytology was performed to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using flow cytometry.

Results

In conclusion, both artificial tears improve dry eye signs and symptoms and inflammatory markers expression artificial tears decreased inflammatory markers in dry eye patients.