Topical application of hyaluronic acid and chondroitin sulfate in the treatment of dry eyes.
This clinical trial was published in 1987 in Journal Am J Ophthalmol. (IF2017: 4.795). Twenty patients with keratoconjunctivitis sicca used three different viscoelastic tear formulations and a polyvinyl alcohol artificial tear for two weeks each. Each formulation was used once every two waking hours in a controlled double-masked study.
Corneal staining and mucous strand formation were also reduced in patients with these manifestations. No formulation was preferred by a majority of patients or proved superior in treating signs of keratoconjunctivitis sicca.