Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography

Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomogr.jpg

Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography. A randomized, single-masked, observer-blinded parallel group, Multicentral, Clinical trial.

Article specifications

This clinical trial was published in 2017 in Acta ophthalmologica journal (IF 2015:3.157) by ophthalmologists in Austria.

In this study, the changes in pre corneal tear film thickness (TFT) after administration of these 3 gel-based lubricants indicated for 60 patients with dry eye disease (DED) were compared:

  1. TH-HA: Trehalose 3%, hyaluronic acid 0.15%, carbomer 0.25%, sorbitol, sodium hydroxide and water.
  2. HA: Hyaluronic acid 0.2%, citrate buffer, sorbitol and water.
  3. PG-PRG: Polyethylene glycol 0.4%,propylene glycol 0.3%, hydroxypropyl guar, sorbitol, aminomethylpropanol, boric acid, potassium chloride, sodium chloride, disodium EDTA, polyquad® preservative 0.001% and water.

Measurements of TFT were repeated 10, 30, 60, 120, 240 and 360 min after instillation. After the last measurement, the assessment of patient’s satisfaction (subjective evaluation of ocular comfort), visual acuity, BUT and Schirmer I test were performed.

Results

In conclusion, significant differences in TFT after administration of the three lubricant gels were observed in the present study but there were no significant differences between the three study groups. All eye drops lead to a significant increase in TFT 10 min after administration, which was most pronounced with PG-PRG. As compared to the other products, HA-TH offers a longer lasting increase in TFT reflecting a longer residence time on the cornea.

Tags: Austria Acta ophthalmologica Clinical trial 2017

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