Effectiveness of hyaluronan on corneal epithelial barrier function in dry eye

Effectiveness of hyaluronan on corneal epithelial barrier function in dry eye.jpg

Effectiveness of hyaluronan on corneal epithelial barrier function in dry eye.

Article specifications

This Randomize, Clinical trial was published in 1997 in British journal of ophthalmology (IF 2017:3.806) by Japanese ophthalmologists. This study evaluated the effect of hyaluronan (0.1% hyaluronic acid (mean molecular weight: 60–120 Da)) on Corneal epithelial barrier function in dry eye syndrome. Eleven patients with dry eye, aged 43–84 years (mean 60.5 (SD 13.7) years), seven with Sjögren’s syndrome and four without, were assigned to this study. In this study hyaluronan and artificial tear (NaCl and KCl, no preservatives, at a pH of 6.0–7.0, and an osmolarity ratio  of 0.9–1.1, was applied to the right eye 5 times a day and only hyaluronan in left eye.  Fluorophotometry was used to measure fluorescein uptake at the central and lower corneal portions.

Results

This study suggested that hyaluronan is effective in proving corneal epithelial barrier function through its ability to promote corneal epithelial cell migration, as well as by its water retentive properties, is not clear.                                     

Tags: Japan British journal of ophthalmology Clinical trial 1997

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