Efficacy of 0.18% hypotonic sodium hyaluronate ophthalmic solution in the treatment of signs and symptoms of dry eye disease. A Randomize, Multicenter, phase III Clinical trial.
This clinical trial was published in 2012 in Journal Français D'Ophtalmologie (IF 2016:0.567) by swiss ophthalmologists. In this study the efficacy and safety of hypotonic 0.18% sodium hyaluronate solution (0.18% SH) was compared with saline and 0.3% carbomer for the treatment of signs and symptoms of moderate dry eye syndrome.
304 patients were randomized to receive one drop of 0.18% SH (n = 106) or saline (n = 101) or carbomer (n = 97) in each eye two to four times per day during 84 days. The efficacy and safety of treatments were evaluated.
Results of the study showed that 0.18% sodium hyaluronate has better safety and tolerate in compare with saline and as well as carbomer and also lower number of instillations required with sodium hyaluronate.