Comparison between Hyalgan and Adant

Intra-articular Treatment with Hyaluronic Acid Comparative Study of Hyalgan and Adant

Article specifications

This original article was published in 2000 in Journal of Clin Rheumatol (IF 2015:2.042) by Spanish specialist. The purpose of this randomized study was to compare two types of Intra-Articular Hyaluronic acid. Forty-nine patients diagnosed as having gonarthrosis following clinical and radiological criteria (states II and III according to Kellgren and Lawrence) were included in a blind randomized study.

Adant: 5 injections of 25 mg (2.5 ml). This is a 1% sodium hyaluronate solution with a mean molecular weight of 900 000 D biotechnically obtained.

Hyalgan: 5 injections of 20 mg (2 ml). This is a 1% sodium hyaluronate solution with a mean molecular weight of 800 000 D from an animal source. A total of 49 intra-articular treatments (245 infiltrations) were carried out on 49 patients, of whom 30 were given Adant and 19 Hyalgan.

 

Results

The efficacy with Adant at 3 months (50%) after treatment was greater than with Hyalgan (21.1%), probably because of its greater viscosity increases its half-life in the joint. The maximum improvement was seen at 5 weeks in 75.4% and decreased gradually with time. Thus, if the treatment is effective it is necessary to consider restarting the treatment at 6 months.