Safety and tolerability of intra-articular hyaluronic acid (Sinovial®/GELSYN-3tm) injections in the treatment of knee osteoarthritis

Safety and tolerability of intra-articular hyaluronic acid (Sinovial^®GELSYN-3tm) injections in the treatment of knee osteoarthritis.

Article specifications

This clinical trial was published in 2017 in Journal of J Biol Regul Homeost Agents. (IF2013: 1.90) by Italian specialists. This expert opinion reports on the published data regarding the efficacy and tolerability of first and multiple injection series of Sinovial^®-based product formulations. The data regarding the tolerability of Sinovial^® in patients with knee osteoarthritis were analyzed.

 

Results

This formulation, beside favourable therapeutic effects, has a very good tolerability profile, with only mild, transient, and easily managed, local injection-site reactions and absence of systemic reactions. In particular, repetitive cycles of HA have been shown to yield positive results in terms of both efficacy and safety and therefore should be offered to patients who had undergone a successful first course of therapy when their symptoms reoccur.