Comparison the long-term effect of intraarticular injection of PRP and HA on clinical outcome and quality of life of patients with knee OA

Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial).

Article specifications

This clinical trial was published in 2015 in Journal of Clin Med Insights Arthritis Musculoskelet Disord. (IF 2015:3.25) by Iranian specialists. The aim of our study was to compare the long-term effect of intraarticular injection of PRP and HA on clinical outcome and quality of life of patients with knee OA. This non-placebo-controlled randomized clinical trial involved 160 patients affected by knee OA, grade 1-4 of Kellgren-Lawrence scale. In the PRP group (n = 87), two intra-articular injections at 4-week interval were applied, and in the HA group (n = 73), three doses of intra-articular injection at 1-week interval were applied. 

 

Result

At the 12-month follow-up, WOMAC pain score and bodily pain significantly improved in both groups; however, better results were determined in the PRP group compared to the HA group. This study suggests that PRP injection is more efficacious than HA injection in reducing symptoms and improving quality of life and is a therapeutic option in select patients with knee OA who have not responded to conventional treatment.