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Compare the efficacy and safety of intra-articular hyaluronic acid and oxygen-ozone in the treatment of knee OA

Intra-articular ozone or hyaluronic acid injection: which one is superior in patients with knee osteoarthritis: a 6-month randomized clinical trial.

Article specifications

This clinical trial was published in 2018 in Journal of J Pain Res. (IF 2016:2.581) by Iranian specialists. A total of 174 patients with more than 3 months of chronic pain or swelling in the knee joints along with consistent imaging findings were enrolled and randomly allocated into two groups of HA and ozone, which were planned to undergo 3 weekly injections of HA (Hyalgan®) and 10 mL of a 30 μg/mL ozone solution, respectively.

 

Result

No major adverse events were detected in this study. Although both ozone and HA can be effectively used for improving function and reducing pain in selected knee OA patients, neither of the two showed any superiority at 6-month follow-up.

Tags: Iran Clinical trial 2018 J Pain Res

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