Comparing efficacy of hyaluronic acid and betamethasone for intra-articular injections

Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone

Article specifications

This clinical trial was published in 2015 in Journal of Open Access Rheumatol. (IF 2015:0.33) by Spain and Mexico specialists. We evaluate HA and CS in patients with knee OA in terms of clinical efficacy over 12 months. We used a prospective, randomized study with parallel groups. Randomized patients received IA injections of HA or betamethasone (BM). The primary outcomes were improvement in pain using Visual Analog Scale and function in the Western Ontario and McMaster University Osteoarthritis Index (Likert scale). Follow-up visits were scheduled at 3 months, 6 months, 9 months, and 12 months.

 

Result

The results of this study showed that both treatments effectively controlled OA symptoms. BM showed higher short-term effectiveness, while HA showed better long-term effectiveness, maintaining clinical efficacy in a large number of patients 1 year after administration.