Changes of synovial fluid protein concentrations in supra-patellar bursitis patients after the injection of different molecular weights of hyaluronic acid

Changes of synovial fluid protein concentrations in supra-patellar bursitis patients after the injection of different molecular weights of hyaluronic acid.

Article specifications

This clinical trial was published in 2014 in Journal of Exp Gerontol. (IF 2015:1.88) by Taiwan specialists. This study aimed to identify the concentration changes in the synovial fluid total protein amount and individual proteins associated with supra-patellar bursitis using the Bradford protein assay and western immunoglobulin methods. A total of 20 patients were divided into two groups with 10 patients in each group. One group received the high molecular weight hyaluronic acid product of Synvisc Hylan G-F 20 and the other group received the low molecular weight hyaluronic acid product of Hya-Joint Synovial Fluid Supplement once per week injection into the bursa for a total of 3 weeks.

 

Result

After the completion of the HA injections to the bursa, proteins associated with lipid transport and inflammation (e.g. apolipoprotein A-I and interleukin 1 beta) are decreased. This may be the likely cause of the observed decrease in SF total protein concentration after the second dosage of HMW HA injection. On the other hand, concentration of the protein with anti-aging effect (e.g. TTR) is significantly increased after both LMW and HMW HA injections. As a result, the rheology of SF in supra-patellar bursitis patients is changed after HA injections, with obvious concentration decreases in inflammatory and lipid transport proteins, and with concentration increases in anti-aging protein.