Avoidance of Total Knee Arthroplasty in Early Osteoarthritis of the Knee with Intra-Articular Implantation of Autologous Activated Peripheral Blood Stem Cells versus Hyaluronic Acid

Avoidance of Total Knee Arthroplasty in Early Osteoarthritis of the Knee with Intra-Articular Implantation of Autologous Activated Peripheral Blood Stem Cells versus Hyaluronic Acid: A Randomized Controlled Trial with Differential Effects of Growth Factor Addition.

Article specifications

This clinical study was published in 2017 in Journal of Stem Cell Int. (IF 2015: 4.10) by Thailand specialists. Sixty patients were recruited for the present study and were randomized to one of three treatment groups, group 1 received the combination of IAAAPBSC with GFA consisting of platelet-rich plasma(PRP) and hG-CSF along with HA (2 ml Ostenil®, MW = 1.2 Mdal) in conjunction with arthroscopic MCS, while group 2 (17 F/3 M) received the same combination with the exception of hG-CSF. Patients in group 3 (14 F/6M) only received IA-HA without any arthroscopic surgery.

Each group received one weekly injection for 3 consecutive weeks and was evaluated at 0, 1, 6, and 12 months, with the primary endpoint and secondary endpoint being avoidance of TKA intervention and WOMAC scores, respectively.

 

Result

There were no notable adverse events. We have shown avoidance of TKA in the AAPBSC groups at 12 months and potent, early, and sustained symptom alleviation through GFA versus HA alone. Differential effects of hG-CSF were noted with an earlier onset of symptom alleviation throughout.

Tags: Thailand Clinical trial 2017 Int J Biol Macromol

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