Interactions between hyaluronic acid and phospholipids at various functionality levels during normal and pathological synovial fluid conditions

Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis.

Article specifications

This study was published in 2017 in Journal of Int J Mol Sci. (IF 2017:3.687) by Poland specialists. The purpose of this study is to evaluate interactions between hyaluronic acid and phospholipids at various functionality levels during normal and pathological synovial fluid conditions.

 

Result

The results demonstrated that phospholipids affect the crosslinking mechanisms of hyaluronic acid significantly and the influence is higher during pathological conditions. During normal conditions, hyaluronic acid and phospholipid interactions seem to have no competing mechanism to that of the interaction between hyaluronic acid to hyaluronic acid.