Examine the long-term efficacy and safety of five intra-articular injections with hyaluronan in knee osteoarthritis

Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year.

Article specifications

This clinical trial was published in 2010 in Journal of Ann Rheum Dis. (IF 2010: 7.05) by Danish specialists. This study aimed to examine the long-term efficacy and safety of five intra-articular injections with hyaluronan in knee osteoarthritis. A multicentre, randomised, placebo-controlled double-blind study of 337 patients fulfilling the American College of Rheumatology (ACR) criteria for knee osteoarthritis (clinical and laboratory) and with a Lequesne algofunctional index score (LFI) of 10 or greater.

 

Results

In patients fulfilling the ACR criteria for osteoarthritis of the knee with moderate to severe disease activity (LFI > or = 10), five intra-articular injections of hyaluronan did not improve pain, function, paracetamol consumption or other efficacy parameters 3, 6, 9 and 12 months after the treatment.