Addition of Sorbitol to Hyaluonic acid may reduce the onset of action of viscosupplementation in patients with symptomatic knee osteoarthritis
This clinical study was published in 2011 in Journal of Osteoarthritis and Cartilage (IF 2015:1.05) by Swiss specialists. The purpose of this study was to evaluate the short term pain-relief effect of ANTI-OX-VS in patients suffering from KOA. thirteen-week (W) prospective open pilot study 30 patients suffering from symptomatic KOA (tibiofemoral and/or patellofemoral, grade 2 to 4) were treated by intra-articular injections of ANTI-OX-VS. Each patient received 3 intra-articular injections of 2 mL one week apart.
This exploratory study suggests a quick and strong pain relief occurring immediately after the first injection of ANTI-OXVS, followed by a continuous improvement until the end of follow-up. Improvement was achieved much faster than that obtained with other viscosupplements probably because of the presence of high concentrations of sorbitol through its antioxidant activity. These data support the need for a large-scale, prospective clinical trial comparing the safety and long term efficacy of ANTI-OX-VS to regular viscosupplement.