Differences in efficacy and safety of available IA-HA injections for knee OA

Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee.

Article specifications

This Meta-analysis was published in 2016 in Journal of Am J Sports Med. (IF 2016:5.673) by American, Canadian, Swedish and Indian specialists. The aim of our study is to determine whether there are differences in efficacy and safety with respect to intrinsic properties of available IA-HA injections for knee OA. A comprehensive literature search of the Medline, EMBASE, and PubMed databases was conducted for all existing randomized trials of IA-HA. The primary outcome measure analyzed was the mean pain score at the reported follow-up nearest to 26 weeks after injection.

 

Result

Despite similarities, IA-HA products should not be treated as a group, as there are differences in IA-HA products that influence both efficacy and safety. In the available literature, IA-HA products with a molecular weight ≥3000 kDa and those derived from biological fermentation relate to superior efficacy and safety-factors that may influence selection an IA-HA product for OA of the knee.