The effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One®, medium MW Viscoplus® and high MW Durolane®, on chondrocyte proliferation and collagen type II (COL2A1), hypoxia-inducible factor 1α (HIF-1α) and

The association between different molecular weights of hyaluronic acid and CHAD, HIF-1α, COL2A1 expression in chondrocyte cultures.

Article specifications

This clinical trial was published in 2018 in Journal of Exp Ther Med. (IF2018: 0.62) by Turkish specialists. The aim of the present study was to investigate the effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One^®, medium MW Viscoplus^® and high MW Durolane^®, on chondrocyte proliferation and collagen type II (COL2A1), hypoxia-inducible factor 1α (HIF-1α) and chondroadherin (CHAD) expression in primary chondrocyte cultures.

 

Results

In terms of increased viability and proliferation, a longer duration of HA application was more effective. Taken together, it may be concluded that the administration of medium and high MW HA may be a successful way of treating diseases affecting chondrocytes in a clinical setting. The present study demonstrated that HA administration at different molecular weights to cell cultures, over short periods (24 and 48 h) changed the expression of certain genes. However, clinicians should consider the cellular effects of HA molecular weight in the treatment of OA.