Compare the effectiveness of three injections of standard linear HA versus single injection of lightly cross-linking HA in patients with knee OA

Single versus multiple dose hyaluronic acid: Comparison of the results.

Article specifications

This clinical trial was published in 2016 in J Back Musculoskelet Rehabil. (IF2016: 0.60) by Turkish specialists. The purpose of this study was to compare the effectiveness of three injections of standard linear HA versus single injection of lightly cross-linking HA in patients with knee OA. Forty subjects were randomized into two groups. The first group received single dose intraarticular injection of 4 ml lightly cross-linking sodium hyaluronate (Monovisc), and the second group received three consecutive intraarticular injections of 2.5 ml standard linear sodium hyaluronate (Adant) with one week intervals.

 

Results

Results of this clinical trial showed that Although three-dose administration was significantly superior to single-dose at the sixth month, current knowledge is not sufficient to decide whether single-dose or multiple-dose HA injection should be chosen. There is a clear need for verification of our results with long-term studies on larger patient groups.