Compare the elastoviscous properties of a high-molecular-weight viscosupplement with lower-molecular-weight hyaluronan (LMW HA) product

The role of elastoviscosity in the efficacy of viscosupplementation for osteoarthritis of the knee a comparison of hylan G-F 20 and a lower-molecular-weight hyaluronan.

Article specifications

This clinical trial was published in 1999 in Journal of Clin Ther. (IF 2007: 3.98) by American specialists. The aim of the present study was to compare the elastoviscous properties of a high-molecular-weight viscosupplement, hylan G-F 20 (polymer concentration, 0.8%), with those of a lower-molecular-weight hyaluronan (LMW HA) product (polymer concentration, 1%) and to determine the relationship of elastoviscosity to efficacy in the treatment of patients with osteoarthritis (OA) of the knee.

 

Results

The difference in the incidence of adverse events between groups was not statistically significant. The higher-molecular-weight, more elastoviscous hylan G-F 20 had significantly greater pain-relieving effects than did the lower-molecular-weight, less elastoviscous hyaluronan.