Click-crosslinked hyaluronic acid (HA) (Cx-HA) depot for direct intra-articular injection into joints affected by rheumatoid arthritis
Injectable Click-Crosslinked Hyaluronic Acid Depot To Prolong Therapeutic Activity in Articular Joints Affected by Rheumatoid Arthritis.
Article specifications
This study was published in 2017 in Journal of ACS Appl Mater Interfaces. (IF 2018: 7.31). The aim of this study was to design a click-crosslinked hyaluronic acid (HA) (Cx-HA) depot via a click crosslinking reaction between tetrazine-modified HA and trans-cyclooctene-modified HA for direct intra-articular injection into joints affected by rheumatoid arthritis (RA).
Results
MTX-Cx-HA injected intra-articularly persists at the joint site in therapeutic MTX concentrations for an extended period, thus increasing the duration of RA treatment, resulting in an improved relief of RA.