Effectiveness of different types of hyaluronic acid preparations on pain and function of inpatients with knee osteoarthritis

Efficacy of single-dose hyaluronic acid products with two different structures in patients with early-stage knee osteoarthritis.

Article specifications

This clinical trial was published in 2016 in Journal of J Phys Ther Sci. (IF2016: 1.21) by Turkish specialists. The aim of this trial was to investigate the effectiveness of different types of hyaluronic acid preparations on pain and function of inpatients with knee osteoarthritis. All patients were diagnosed by clinical examination and x-ray. Ostenil PLUS® was injected into 28 patients (group 1, 1.6 million daltons), and MONOVISC® (group 2, 2.5 million daltons) was injected into 46 patients.

 

Results

The study presented here demonstrated that both single-dose HA preparations were effective in terms of pain and function. Improvements in VAS and all WOMAC scores were noted at 1 month post injection and persisted at 3 and 6 months post injection in both groups. Comparison of the groups revealed no significant difference except for in the WOMAC stiffness score. The improvement in the WOMAC stiffness score achieved with Ostenil PLUS® was first noted at 1 month and persisted subsequently. The improvement in WOMAC stiffness score achieved with MONOVISC® was first noted at 1 month, but the improvement did not persist at 3 and 6 months.