RA therapy with natural molecules without side effects possessing anti-inflammatory and anti-oxidative properties
Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis in vivo.
Article specifications
This study was published in 2010 in Journal of Neuro Endocrinol Lett. (IF 2016:0.918) by Slovakian specialists. The aim is to find an additive to classical RA therapy with natural molecules without side effects possessing anti-inflammatory and anti-oxidative properties.
Results
CARN proved its inhibitory properties against degradation of HA solutions at experimental conditions in vitro and showed its beneficial efficiency in vivo. Moreover, it reduced also hind paw volume (HPV), the clinical marker of inflammation in adjuvant arthritis (AA).