Effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators

Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.

Article specifications

This clinical trial was published in 2014 in Journal of Osteoarthritis Cartilage. (IF2017: 5.454) by Japanese specialists. The aim of this study was to determine the effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators induced by interleukin 1β (IL-1β) and related to cartilage catabolism in murine osteoblasts.

 

Results

High-MW CL HA exerts potential chondroprotective effects and produces superior friction coefficients. Our results suggest that HA600 delays the progression of OA effectively and improves joint lubrication significantly.

 

Tags: Japan osteoarthritis and cartilage Clinical trial 2014

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