Effect of IA Hylan GF-20 injections on synovial fluid

Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.

Article specifications

This clinical trial was published in 2006 in Journal of J Rheumatol. (IF2006: 2.04) by Australian specialists. The aim of this study was to determine the effect of IA Hylan GF-20 injections on synovial fluid (SF) hyaluronan (HA) concentration, viscosity, and elasticity over a 6-month period in patients with mild to moderate OA of the knees.

 

Results

This open-label study showed a statistically significant change from baseline in both SF HA concentration and complex shear modulus at 3 months following IA Hylan GF-20 injection among subjects with mild to moderate knee OA. These results suggest that one possible mechanism of action of viscosupplementation is to promote endogenous HA production. Longer-term studies are required to identify whether these changes in SF measures are important for modification of disease progression in knee OA.